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Here, we used PET and [ 11 C]-(+)-PHNO ([ 11 C]-(+)-4-propyl-3,4,4a,5,6,10b-hexahydro-2H-naphtho[1,2-b][1,4]oxazin-9-ol) to test the hypothesis that smoking increases DA release (decreases [ 11 C]-(+)-PHNO binding) in D2-rich striatum and D3-rich extra-striatal regions and is related to craving, withdrawal and smoking behavior

The longer-term effects can stick around longer, especially if youre vaping regularly

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